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Cyclosporin D
CAS No. 63775-96-2
Cyclosporin D( —— )
Catalog No. M30364 CAS No. 63775-96-2
Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCyclosporin D
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NoteResearch use only, not for human use.
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Brief DescriptionCyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.
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DescriptionCyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.(In Vitro):Cyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro.(In Vivo):Cyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin.
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In VitroCyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro.
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In VivoCyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin.
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Synonyms——
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PathwayApoptosis
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TargetIL Receptor
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number63775-96-2
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Formula Weight1216.64
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Molecular FormulaC63H113N11O12
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (20.55 mM)
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SMILES——
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Chemical NameSequence:cyclo ({Aaa}-Val-{Sar}-Leu-Val-Leu-Ala-Ala-Leu-Leu-{d-Val})
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Gschwendt M, et al. The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Biochem Biophys Res Commun. 1988 Jan 29;150(2):545-51.
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